Tumor-associated trypsin inhibitor.
نویسنده
چکیده
Tumor-associated trypsin inhibitor (TATI) is a low-molecular-weight (6 kDa) trypsin inhibitor that has been used as a marker for ovarian cancer. It is also expressed together with tumor-associated trypsin by many other tumors, and increased serum concentrations of TATI occur in connection with these. TATI is a prognostic marker for ovarian, bladder, and kidney cancer, which may be associated with the participation of trypsin in protease cascades contributing to tumor invasiveness.
منابع مشابه
Concentrations of tumor-associated trypsin inhibitor and C-reactive protein in serum in acute pelvic inflammatory disease.
We measured tumor-associated trypsin inhibitor (TATI) and C-reactive protein (CRP) in serum of 29 patients with proven pelvic inflammatory disease (PID). TATI values were increased in seven (24%), paralleling increases in CRP. TATI was increased by about 3.5-fold in seven of eight patients with CRP concentrations greater than 90 mg/L, but in none of 21 patients with CRP concentrations less than...
متن کاملEffects of Protease Inhibitors on Growth of Hamster Tumor Cells in Culture1
Beef pancreas trypsin inhibitor has been shown to promote parallel alignment of hamster tumor cells in culture and to increase the adhesiveness of rounded cells. It has a slightly depressing effect upon cell proliferation. Soybean inhibitor depressed cell proliferation but had no effect upon cell alignment. Egg white inhibitor had no effect upon proliferation or cell alignment. The synthetic pr...
متن کاملEffects of protease inhibitors on growth of hamster tumor cells in culture.
Beef pancreas trypsin inhibitor has been shown to promote parallel alignment of hamster tumor cells in culture and to increase the adhesiveness of rounded cells. It has a slightly depressing effect upon cell proliferation. Soybean inhibitor depressed cell proliferation but had no effect upon cell alignment. Egg white inhibitor had no effect upon proliferation or cell alignment. The synthetic pr...
متن کاملEmerging Roles of SPINK1 in Cancer.
BACKGROUND Tumor-associated trypsin inhibitor (TATI) was originally isolated from the urine of a patient with ovarian cancer. It was later shown to be produced by many other tumors and several normal tissues. It had earlier been isolated from the pancreas and was hence called pancreatic secretory trypsin inhibitor (PSTI). It belongs to a family of protease inhibitors presently called serine pep...
متن کاملImmunohistochemical Detection of Pancreatic Secretory Trypsin Inhibitor (PSTI) in Urothelial Cancer
Pancreatic secretory trypsin inhibitor (PSTI), a specific trypsin inhibitor secreted by acinar cells of pancreas, also acts as a growth factor. PSTI in various cancers has been reported to be associated with tumor invasiveness and pathological malignancy; however, such studies in urological cancers have not yet been performed. We therefore examined the expression of PSTI in fresh frozen specime...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinical chemistry
دوره 48 8 شماره
صفحات -
تاریخ انتشار 2002